The Pisan Multidisciplinary Center on Research and Clinical Implementation of Flash Radiotherapy (CPFR) was recently established in Pisa, which synergistically combines the various experiences and scientific and clinical skills of excellence expressed by the territory and involving the

University of Pisa, the Pisan University Hospital, the CNR – Neuroscience Institute, and INFN National Institute of Nuclear Physics. The CPFR is equipping itself with a linear electron accelerator (LINAC).

The device has been specially designed and developed for CPFR and will be equipped with a TRIODE electron gun, a unique feature among the sources of this type that should enable a series of decisive experiments to understand the mechanism of Flash Therapy.

The Flash effect is a radiobiological effect, experimentally shown on animal models, which allows, by delivering the dose of radiotherapy in fractions of a second (compared to minutes of conventional radiotherapy),

to drastically save damage to healthy tissues while maintaining the effectiveness therapy on cancer. This would allow, if translated into clinical practice, to be able to increase the therapeutic doses and volumes involved, thus effectively treating tumors with a disastrous prognosis to date.

The CPFR center was established within CISUP (Center for the Integration of Instrumentation of the University of Pisa), and is a candidate to become an international reference center on a topic of absolute importance, both from a scientific and from that of clinical perspectives.

“When the Pisa Foundation was asked by the University of Pisa to participate with financial support in the research on the FLASH effect, we carried out the usual investigation aimed at verifying the recurrence in the circumstance of all the essential conditions for us, noting that in recent years the ‘interest in this research has translated into a growing scientific production – explained Stefano

Del Corso, president of the Pisa Foundation – however the experimental results have so far provided only partial data because the experiments have been limited by the use of common accelerators as they are not designed for this purpose.

The Pisa Foundation has therefore decided to support the hypothesized line of research, which provides, among the few in the world, the use of a specific accelerator for radiotherapy

-flash, together with the possibility of combining in a single center multidisciplinary skills to design and execute experiments that accurately evaluate the effects tti, in order to bring the FLASH effect into clinical routine in the future. This is at least the hope that supports our choice “.

“Thanks to the signing of this agreement – declared the rector of the University of Pisa, Paolo Mancarella – Pisa will be the first Italian city and one of the four cities in the world to have an interdisciplinary center dedicated to the experimentation of Flash Radiotherapy.

our community can only be immensely grateful to the Pisa Foundation which, with its fundamental financial support, makes its realization possible “. “The goal we set ourselves – he continued – is ambitious: to be the first in Italy to obtain authorization for clinical trials on humans of this therapy which, up to now, has only been tested once with results, they tell me. , which are almost miraculous “.


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